Week 2 fantasy rankings and injury updates drive start/sit decisions in PPR leagues. Christian McCaffrey is cleared for Week 2, while Brock Purdy is out, shifting SF’s offensive plan. Darren Waller is ruled out for the Giants, narrowing Giants’ passing targets. Drake London projects as a low-end WR1 with upside, and Dallas Goedert is sidelined, impacting Eagles’ tight-end run. Top-tier players remain front-and-center: McCaffrey, Gibbs, Bijan Robinson, CeeDee Lamb, Ja’Marr Chase, and Justin Jefferson, with Ridley, Evans, and Walker as reliable mid-to-high-floor options.

Christian McCaffrey is cleared for Week 2, anchoring the top tier, while Bijan Robinson, Jahmyr Gibbs and Saquon Barkley headline the early-season map. Pollard’s workload keeps him in low-end RB2 territory, with Seattle’s backfield trending toward a split between Charbonnet and Walker. Week 2 values hinge on volume, matchup, and pass-game involvement across backfields.

TreVeyon Henderson could see more work in New England, D’Andre Swift needs a TD to reach value, and James Cook returns for Buffalo as backfields normalize. The outlooks emphasize volume, pass-game usage, and injury updates to sharpen start-sit decisions and DFS lines.

Week 2 fantasy QB rankings for 2025 spotlight the same mix of elite ceiling and plus-matchup upside that fantasy managers crave. Justin Fields’ rushing floor keeps him in QB1 territory, while Caleb Williams anchors a high-upside Bears offense as a top weekly option in Superflex. Mac Jones enters with a favorable Saints test, and Patrick Mahomes faces a stiff challenge in a rematch against Philadelphia. J.J. McCarthy and Michael Penix Jr. sit as strong Superflex plays, with several veterans and youngsters rounding out the top tiers.

The Week 2 outlook emphasizes risk-reward: injuries and known blockers shift the value of several signal-callers, from Purdy’s out to Mahomes’ matchup dynamics, shaping lineup decisions for fantasy managers who need big weeks from their QBs to carry squads into the weekend.